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pandora necklaces Two independent reviewers evaluated 116 potentially relevant studies, and 12 records (13 randomised controlled trials) met the criteria to be included in this review, with one article reporting results of two trials (fig 1).43 44 45 46 47 48 49 50 51 52 53 54 Ten trials reporting data from 3541 patients evaluated the efficacy of paracetamol in patients with osteoarthritis of the hip or knee,43 44 46 47 48 49 50 51 54 and three trials (1825 patients) investigated the efficacy of paracetamol in people with low back pain.45 52 53 We did not identify any trials in patients with neck pain. Overall, the included trials assessed 5366 patients. One trial, however, reported the use of intravenous paracetamol in participants with chronic low back pain.52 The total oral dose and dose regimens for paracetamol varied across trials, with 10 trials using a total dose of 3900 4000 mg/day and three trials using 3000 mg/day (table 1). pandora necklaces
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